tag:blogger.com,1999:blog-9633767.post1858896710633291310..comments2024-03-25T09:11:17.877-07:00Comments on The Curious Wavefunction: A rash of molecular personalitiesWavefunctionhttp://www.blogger.com/profile/14993805391653267639noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-9633767.post-13049705437040691542008-03-15T07:09:00.000-07:002008-03-15T07:09:00.000-07:00Good point. Although in this study they turn out t...Good point. Although in this study they turn out to be irreversible too. I would think that covalent inhib is more common for hydrolytics, but I would like to see a survey.Wavefunctionhttps://www.blogger.com/profile/14993805391653267639noreply@blogger.comtag:blogger.com,1999:blog-9633767.post-3385208363849277542008-03-15T01:36:00.000-07:002008-03-15T01:36:00.000-07:00Covalency should not be equated with irreversibili...Covalency should not be equated with irreversibility. I'm not particularly famiiar with the MS experiments (and can't currently see the article) but I'm assuming that they will be unable to detect a protein adduct if the off-rate is too high. One question you need to be asking is whether covalent inhibition is more common for hydrolytic enzymes.Georg-Martin Krapperhttps://www.blogger.com/profile/15416686863175197568noreply@blogger.com