tag:blogger.com,1999:blog-9633767.post2891712085594446324..comments2024-03-25T09:11:17.877-07:00Comments on The Curious Wavefunction: Overturning hydrophobic assumptionsWavefunctionhttp://www.blogger.com/profile/14993805391653267639noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-9633767.post-24434432277243818762011-11-09T03:13:13.248-08:002011-11-09T03:13:13.248-08:00"If it's not then it's going to be bo..."If it's not then it's going to be both an entropic and enthalpic gain. "<br /><br />You mean an entropic loss and enthalpic gain? Water in bulk is really quite ordered.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-49138543054791973932011-11-08T07:28:54.600-08:002011-11-08T07:28:54.600-08:00It depends on whether the water molecule is bonded...It depends on whether the water molecule is bonded to hydrogen bonding groups in the protein. If it's not then it's going to be both an entropic and enthalpic gain. If it is then the enthalpy will stay pretty much the same (the hydrogen bonds will be swapped), but the greater freedom will still contribute to favorable entropy.Wavefunctionhttps://www.blogger.com/profile/14993805391653267639noreply@blogger.comtag:blogger.com,1999:blog-9633767.post-26550511882794674832011-11-08T03:05:00.441-08:002011-11-08T03:05:00.441-08:00"The textbooks will also tell you that the hy..."The textbooks will also tell you that the hydrophobic effect is favorable principally because of entropy"<br /><br />When you displace a water molecule in a protein pocket, and move it to bulk water, it will usually be a net entropic loss, but enthalpic win. It seems that this effect is often larger than the old textbook explanation.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-15895860326592191802011-11-04T00:49:25.959-07:002011-11-04T00:49:25.959-07:00Interesting read about a little discussed topic on...Interesting read about a little discussed topic on chemistry blogs. It offers stimulating ideas for further study. Worth sharing among chemists.cocoon bobbinshttp://cocoon-bobbins.comnoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-74663093805976174512011-11-03T21:55:53.190-07:002011-11-03T21:55:53.190-07:00Really? You felt the need to say compensation?Really? You felt the need to say compensation?Anonymousnoreply@blogger.com