tag:blogger.com,1999:blog-9633767.post300756007934723925..comments2024-03-25T09:11:17.877-07:00Comments on The Curious Wavefunction: Conquering the curse of morphine, one docked structure at a timeWavefunctionhttp://www.blogger.com/profile/14993805391653267639noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-9633767.post-37442550650096320582016-08-31T22:55:53.479-07:002016-08-31T22:55:53.479-07:00Thank you for writing a piece that so accurately r...Thank you for writing a piece that so accurately recognizes the work and thought process behind this paper. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-25031279974024123142016-08-19T05:02:55.556-07:002016-08-19T05:02:55.556-07:00Yes, I think that's the beauty of it. You can ...Yes, I think that's the beauty of it. You can use new chemistry and modeling to discover new biology.Wavefunctionhttps://www.blogger.com/profile/14993805391653267639noreply@blogger.comtag:blogger.com,1999:blog-9633767.post-22111706903689963692016-08-19T00:09:42.931-07:002016-08-19T00:09:42.931-07:00I particularly liked the part where the authors ad...I particularly liked the part where the authors admit that no matter how smart their approach was, many unique properties of the lead compound were pure luck and wouldn't be possible to predict with current tools. And if Brian Shoichet writes this, I'm pretty sure that nobody in the world can claim otherwise. As a synthetic chemist behind PZM21, I confess that its synthesis in diastereomerically pure form and - especially - figuring out its absolute configuration were quite a luck, too.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-51149883138463599592016-08-18T11:50:56.011-07:002016-08-18T11:50:56.011-07:00Interesting.Interesting.Wavefunctionhttps://www.blogger.com/profile/14993805391653267639noreply@blogger.comtag:blogger.com,1999:blog-9633767.post-72306978136652306222016-08-18T09:35:18.952-07:002016-08-18T09:35:18.952-07:00"Among other insights, detailed studies of GP..."Among other insights, detailed studies of GPCRs have allowed us to determine that the side effects of opioid drugs emerge mainly from engaging one particular protein called ß-arrestin."<br /><br />Ehhh... maybe. Trevena has had a staggeringly difficult time teasing apart side effects and main effects, and when they have, it hasn't been what you'd call perfectly orthogonal to the knockout results.Anonymousnoreply@blogger.com