tag:blogger.com,1999:blog-9633767.post3015679224715689562..comments2024-03-25T09:11:17.877-07:00Comments on The Curious Wavefunction: A potentially revolutionary new technique for chemical structure determinationWavefunctionhttp://www.blogger.com/profile/14993805391653267639noreply@blogger.comBlogger10125tag:blogger.com,1999:blog-9633767.post-70733465386398762002018-10-22T13:01:07.059-07:002018-10-22T13:01:07.059-07:00Ash, I liked how you closed the post by linking to...Ash, I liked how you closed the post by linking to your earlier post on scientific convergence(which I had enjoyed reading) and couldn't agree with you enough on it. Everything old gets re-looked at now and then when such inventions come along.Anonymoushttps://www.blogger.com/profile/13914084125449101328noreply@blogger.comtag:blogger.com,1999:blog-9633767.post-54031386420976860512018-10-19T12:15:53.514-07:002018-10-19T12:15:53.514-07:00It should be the same as with x-ray diffraction, w...It should be the same as with x-ray diffraction, which is to say better then carbons. However, you sometimes loose a bit of resolution on the lighter atoms due to the metal dominating the diffraction data. Canageekhttps://www.blogger.com/profile/03770924810559440307noreply@blogger.comtag:blogger.com,1999:blog-9633767.post-69273808488135463912018-10-19T06:18:59.596-07:002018-10-19T06:18:59.596-07:00Ash, after reading the comments in Derek's blo...Ash, after reading the comments in Derek's blog, a Gustavo Santiso-Quinones (who claims to be a coauthor on the ACIE article) states that you need to have some sort of crystallinity. Not sure if the Stoltz paper is EXACTLY the same, but if true, I was right in saying that it seems you cannot use this technique for oils.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-1914798125182364152018-10-19T06:11:33.483-07:002018-10-19T06:11:33.483-07:00I'm no expert on this so I cannot say... But t...I'm no expert on this so I cannot say... But they did not analyze any. Seems that you need a crystal lattice of some kind. Perhaps you can freeze it before analysis, though I don't recall at what temperature this operates/required to operate.<br /><br />And additionally, I'm curious the cost of these. I cannot imagine it's as "cheap" as an NMR and likely requires more electricity, no?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-69150523096832126842018-10-18T18:19:07.193-07:002018-10-18T18:19:07.193-07:00It would be nice to mention the accepted article i...It would be nice to mention the accepted article in ACIE that was published a couple of days ago describing the same technology: https://doi.org/10.1002/anie.201811318Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-80976782327371899752018-10-18T16:06:12.859-07:002018-10-18T16:06:12.859-07:00Would a thin layer of oil on the grid work?Would a thin layer of oil on the grid work?Ash Jogalekarhttps://www.blogger.com/profile/13490235892347190545noreply@blogger.comtag:blogger.com,1999:blog-9633767.post-68256204082192969032018-10-18T14:52:51.700-07:002018-10-18T14:52:51.700-07:00I wonder how molecules containing metals would vis...I wonder how molecules containing metals would visualize? Say, hemoglobin?<br />Oldnukehttps://www.blogger.com/profile/04791120442174416990noreply@blogger.comtag:blogger.com,1999:blog-9633767.post-37700083013426418152018-10-18T11:24:21.141-07:002018-10-18T11:24:21.141-07:00It's common to pipette a few uL of solution di...It's common to pipette a few uL of solution directly onto a TEM grid and let it dry. Atto or femptograms is about right.anon electrochemistnoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-57465073500784013532018-10-18T10:10:27.602-07:002018-10-18T10:10:27.602-07:00Also, they did not analyze oils.Also, they did not analyze oils.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-70862995989890866072018-10-17T15:45:03.518-07:002018-10-17T15:45:03.518-07:00This technique also seems to beat NMR in terms of ...This technique also seems to beat NMR in terms of sample requirements. The femtogram mention in the abstract is a bit absurd -- I'm sure it's impossible to reliably move and track fg flecks of powder from your sample to EM grids, but even if this technique can work on micrograms (or less), it might beat NMR by a few orders of magnitude. tentrillionhttps://www.blogger.com/profile/06470262097820781837noreply@blogger.com