tag:blogger.com,1999:blog-9633767.post3767515979099066842..comments2024-03-25T09:11:17.877-07:00Comments on The Curious Wavefunction: Meta-substitution: challenging a classic textbook paradigmWavefunctionhttp://www.blogger.com/profile/14993805391653267639noreply@blogger.comBlogger11125tag:blogger.com,1999:blog-9633767.post-72606881798352019962010-10-24T05:48:29.649-07:002010-10-24T05:48:29.649-07:00You should update this post since it is well known...You should update this post since it is well known that this work is BS. No need for copper. It's a Friedel crafts reaction. Copper does nothing. All the substrates are engineered to go meta as a natural preference. Bulky electrophile and piv groups ensure this.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-35892403989504660752010-10-22T20:03:25.816-07:002010-10-22T20:03:25.816-07:00ALL BULLSHIT - COPPER NOT NECESSARY
should be ret...ALL BULLSHIT - COPPER NOT NECESSARY<br /><br />should be retractedAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-48691484666303865122009-04-24T13:04:00.000-07:002009-04-24T13:04:00.000-07:00What would you consider to be _the defacto_ books ...What would you consider to be _the defacto_ books to be read in Physical Chem, Organometallics and Inorganic Chem ala clayden et.al. for Organic?<br /><br />Would these make the cut for P.Chem?<br />Mcquarrie, simon and<br />Berry, Price et.al.Srinivasnoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-50045302080006161052009-04-22T19:33:00.000-07:002009-04-22T19:33:00.000-07:00Wavefunction, Did you study in India?Wavefunction, Did you study in India?Srininoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-3948734044417941212009-04-22T07:42:00.000-07:002009-04-22T07:42:00.000-07:00Thanks for the link Srini; it's very interesting. ...Thanks for the link Srini; it's very interesting. Clayden et al. is a spectacular book and while it's still not closely followed in the US, I know people who have now taken note of it. Morrison and Boyd still remains a great textbook and I am sad it was never updated. Among the textbooks used here, I do like Vollhardt and probably Wade. But none of them compares to Clayden et al. You cannot fail to get excited about org chem after reading that book.Wavefunctionhttps://www.blogger.com/profile/14993805391653267639noreply@blogger.comtag:blogger.com,1999:blog-9633767.post-55906190050306684672009-04-22T05:45:00.000-07:002009-04-22T05:45:00.000-07:00I was so happy to see that somebody in the United ...I was so happy to see that somebody in the United States had referred to the forgotten Morrison and Boyd, that I rushed in to comment :-)<br /><br />Only later when I was reading other posts of yours, did I happen to see that the "curious wavefuntion" referred to Ashutosh, (PIO??). And if you had studied in India, obviously you'd know about/ love Morrison and Boyd.<br /><br />My mistakeSrininoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-28909878296035767202009-04-22T05:35:00.000-07:002009-04-22T05:35:00.000-07:00@above
Sorry. URL broke.
pubs.acs.org/cen/educat...@above<br /><br />Sorry. URL broke.<br /><br />pubs.acs.org/cen/education/83/8341education1.htmlSrininoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-64513917027995846882009-04-22T05:32:00.000-07:002009-04-22T05:32:00.000-07:00Morrison and Boyd is the favorite Organic Chemistr...Morrison and Boyd is the favorite Organic Chemistry book in India. Anybody who had to have clear fundamentals was asked to read and solve the problems of M&B. The problem sets start off with the drill problems and go into interesting story based problems (e.g. Experiences of an Inexperienced Graduate Student)<br /><br />I was surprised to know from my friend at Rockefeller that Solomons/Wade/McMurry/others are the textbooks followed in US univs. The most surprising part?? Morrison and Boyd was NOT followed. <br /><br />Clayden,Greeves et. al.,IMO,is at the same position of being a favorite to start learning Organic Chem. However, again in the US, this book is not followed (that's what I heard from my mates who are in grad school).<br /><br />Of course Clayden et.al., follows a different perspective of not ordering the chapters based on functional groups. That is a FIRST. Morrison and Boyd ordered the chapters based on Mechanisms followed in reactions of functional groups, when their peers were just presenting the reactions of functional groups. That was a FIRST in their time, when they released their earliest edition. <br /><br />Clyaden, Greeves et.al., is the Morrison and Boyd of post-Spectroscopy based structural determination.<br /><br />Please see this http://pubs.acs.org/cen/education/83/8341education1.htmlSrininoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-80268589617224541462009-03-25T09:32:00.000-07:002009-03-25T09:32:00.000-07:00That's what I have always found fascinating about ...That's what I have always found fascinating about organic chemistry, that one can always find counterexamples, but not so many that they make it impossible to construct general rules. Thanks for the info on metals.Wavefunctionhttps://www.blogger.com/profile/14993805391653267639noreply@blogger.comtag:blogger.com,1999:blog-9633767.post-88147837080198048732009-03-23T18:30:00.000-07:002009-03-23T18:30:00.000-07:00Violating the sophomore organic rules is nothing n...Violating the sophomore organic rules is nothing new; many metals like Pd, Pt, Ir, and Rh (and many others) are well-known to activate arene C-H bonds. This example is cute cause it demonstrates regioselectivity, which is trickier. Ir-catalyzed arene C-H functionalization is regioselective for 1,3-disubstituted benzenes regardless of what you put on them: addition usually occurs at the 5 position (only in special cases does it not). Pd-catalyzed C-H functionalization is typically ortho-selective.<BR/><BR/>It's also interesting to note that while electrophilic aromatic substitution is slowed down by electron-withdrawing groups, for many transition-metal catalyzed examples, electron-withdrawing groups <I>speed up</I> the substitution (because in EAS benzene is the nucleophile, where in, say, Ir-catalyzed substitution, the metal is). It's a tricksy hobbits.Excimerhttps://www.blogger.com/profile/04159376908782797242noreply@blogger.comtag:blogger.com,1999:blog-9633767.post-19338751611063129002009-03-23T10:27:00.000-07:002009-03-23T10:27:00.000-07:00I haven't seen the perspective supplied by Morriso...I haven't seen the perspective supplied by Morrison, but then I was raised by Streitwieser et al. They did make the same point, but not anywhere near as elegantly.Johnhttps://www.blogger.com/profile/04412324900423436763noreply@blogger.com