tag:blogger.com,1999:blog-9633767.post6702577939980743123..comments2024-03-18T06:11:04.848-07:00Comments on The Curious Wavefunction: A few of my favorite (chemical) things...Wavefunctionhttp://www.blogger.com/profile/14993805391653267639noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-9633767.post-3796874153710398612012-05-10T14:55:14.843-07:002012-05-10T14:55:14.843-07:00Hmm interesting, my partner is a physicist -- what...Hmm interesting, my partner is a physicist -- what did you mean about "The constant opportunities to spar with physicists about the limitations of reductionism"? What ARE the limitations?Ian Davieshttps://www.blogger.com/profile/12086319722692400512noreply@blogger.comtag:blogger.com,1999:blog-9633767.post-85267662272984017242011-02-26T06:59:16.282-08:002011-02-26T06:59:16.282-08:00Yes, that is basically what I mean. So for instanc...Yes, that is basically what I mean. So for instance, in an equilibrium binding or conformational transition event, a difference of 3 kcal/mol between the major and minor species (bound-unbound drug or two conformers) would mean that the minor species is essentially non-existent.Wavefunctionhttps://www.blogger.com/profile/14993805391653267639noreply@blogger.comtag:blogger.com,1999:blog-9633767.post-16050241581688499522011-02-25T07:46:40.650-08:002011-02-25T07:46:40.650-08:00"10. The fact that all of life lives and thri..."10. The fact that all of life lives and thrives within a 3 kcal/mol window and that we still find it enormously challenging to predict energies within 1 kcal/mol"<br /><br />Could you expand on this one ? I find it very intriguing. Do you mean that the net free energy (not the standard one) of all reactions in biology are within -3/+3 kcal/mol ?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-9633767.post-28088330995751482812011-02-25T07:02:45.631-08:002011-02-25T07:02:45.631-08:00True! Wouldn't want to follow up one violent r...True! Wouldn't want to follow up one violent reaction with another.Wavefunctionhttps://www.blogger.com/profile/14993805391653267639noreply@blogger.comtag:blogger.com,1999:blog-9633767.post-19061997725227996962011-02-25T06:57:14.228-08:002011-02-25T06:57:14.228-08:00Freak acid spills really ought to be dealt with us...Freak acid spills really ought to be dealt with using water or weak alkalis you know.Anthony Hardwickehttp://www.twitter.com/AnthHardnoreply@blogger.com