Showing posts with label kinase inhibitors. Show all posts
Showing posts with label kinase inhibitors. Show all posts

All active kinase states are similar but...

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CDK2 bound to inhibitor staurosporine (PDB code: 1aq1) …inactive kinase states are different in their own ways. This admittedly awkward...
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Met/VEGFR/FGFR inhibitors by VS

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This one comes from a NCI group. Starting with a database of 3.5 million compounds, 175 prospective candidates were finally selected for in...
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Selective vs Multitargeted Kinase Inhibitors: Still in the Stone Age

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In the conference on kinase inhibitors I attended recently, there was a panel discussion on the second morning (why do these discussions hav...
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Break

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I am in Boston for a kinase inhibitors conference this week, so I may not be able to blog, except when I want to complain about some kinase ...

"The name's Inhibitor. Kinase Inhibitor"

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Since we were on the topic of kinases a few days back, it is worth pointing out a recent paper by Alex Aronov, Mark Murcko and others at Ve...
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Water-inhibitor synergy in CDKs

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An interesting paper published in the J. Chem. Inf. Mod. investigates the role of water molecules in CDK2 and CDK5 active sites. The author...
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Questions for the kinase biologists

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I am working on a kinase inhibitor design project and I realised that there are some key questions that we need to get answered from the bio...
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