A coterie of pyridines

›
Mohammad Movassaghi of MIT has come up with a versatile new pyridine synthesis using the coupling of amides and pi-electron donors such as...

Carbene 'decarbenized'

›
An interesting exchange has taken place in the pages of Angewandte Chemie. Barbel Shulze and his group at the University of Leipzig claimed ...
2 comments:

Numbers worth knowing

›
For every scientist, there's this bunch of numbers worth knowing, that are a good guide for understanding and predicting stuff. Here...
2 comments:

Daniel Koshland

›
Daniel Koshland of induced fit fame has passed away (or should I say passed on...for a chemist, it's all atoms). Koshland was the chief...

Weird scis-strans observation

›
Not something I expected...the C1-C2 cis form is more stable than the C1-C2 trans form. Both ab initio methods and MMFF say this, and also i...
4 comments:

The BI guys should have used Glide XP Dock

›
In the last post, I was wondering why the BI guys did not use any docking to conjecture the binding mode of their new p38 inhibs. While dock...

BI p38 inhibitors: breaking from the urea

›
Boehringer Ingelheim has a new series of p38 kinase inhibitors (DOI: 10.1021/jm070415w ), where they seek to do something different from the...

Favourite author among 2006 medalists

›
I am happy that the author of my all-time favourite biochemistry textbook is being awarded the National Medal of Science. Others include D...
4 comments:

Is there cause for optimism?

›
I am not a big fan of unfounded optimism based on raw hope, especially in the kind of world that we seem to be living in, where reason is ro...

Book review: Pharmacology for Chemists

›
Pharmacology for Chemists: Joseph G. Cannon, Oxford University Press, 2007 This book is a one stop shop for chemists wanting to be familiar ...