All active kinase states are similar but...

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CDK2 bound to inhibitor staurosporine (PDB code: 1aq1) …inactive kinase states are different in their own ways. This admittedly awkward...
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High-throughput method for detecting intramolecular hydrogen bonds (IHBs)

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We have talked about the importance of intramolecular hydrogen bonds (IHBs) as motifs to hide polar surface area and improve the permea...

Why the new NIH guidelines for psychiatric drug testing worry me

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Chlorpromazine Psychiatric drugs have always been a black box. The complexity of the brain has meant that most successful drugs for t...
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Cosmological inflation, water in proteins and JFK: The enigma of ignorance

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I was immersed in the American Chemical Society's national meeting in Dallas this week, which meant that I could not catch more...

Enthusiasm and promise at the ACS Dallas National Meeting

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I am writing from the Dallas airport from where I am heading out back home after a fantastic national meeting of the American Chemical So...
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Pity the postdoc

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PNAS has an interesting interview with well-known biochemist Greg Petsko about the plight of the postdoc. Postdocs are the main drivers o...
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Hiding hydrogen bonding groups in large druglike molecules

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As most medicinal chemists probably know, one of the major challenges in the field currently is to find out the principles that govern the ...

Digital features in the Journal of Medicinal Chemistry

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J. Med. Chem. has an editorial describing how the journal plans to make structural information in papers more accessible in a digital form...
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What happens when chemists have nothing better to do on a Wednesday afternoon?

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This. It started with me posting a link on Facebook to an awesome recent paper describing physicists' efforts to reweigh the ele...