Trans-biotin?

Questiion for all the synthetics out there: Does anyone know how common, if at all, is trans-biotin, where the two five-membered rings are fused in a trans manner? If not, how easy/hard is it to make it?

3 comments:

  1. This would be quite difficult. Most fused 5,5-ring systems (as found in biotin) are cis only. This is nice in making such molecules as it is almost impossible to make the wrong (trans) isomer

    ReplyDelete
  2. There are a few examples that occur in natural products. For example, there were three papers that appeared just this year reporting a revised structure for palau'amine.

    Tex

    ReplyDelete
  3. Anon: Yep, that's why I was wondering. But maybe I thought there were ways to make them.

    Tex, thanks

    ReplyDelete

Markup Key:
- <b>bold</b> = bold
- <i>italic</i> = italic
- <a href="http://www.fieldofscience.com/">FoS</a> = FoS