"The researchers also found that they could alter the aggressive behaviour of their rats by manipulating the serotonin system. They gave the rats S-15535, a compound that binds exclusively to a neuron 'autoreceptor' that acts to dampen the serotonin system. This autoreceptor is called 5-HT1a. Binding to it seems to bring serotonin levels in the rats back to normal.Hmm...drugs calming down violent rats...now who is going to convince Ann Coulter to enroll in the trial?
When even very low doses of S-15535 were used to bind to the receptors, de Boer found that both the serotonin and the violence of the pathologically aggressive rats returned to normal levels. The much more limited violence of naturally low-aggression rats could also be brought back to normal by the compound — but only by using higher doses. The compound seems to work by ‘fixing’ the serotonin breaking system, which becomes dysfunctional in the super-aggressive rats, says de Boer.