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It is a bit ironic that a group from the same company that saw its drug sink has now come up with a nice crystal structure of the protein to which the drug binds. (Nat. Struc. Mol. Biol., 14, 2, 2007, 106-113)
CETP (Cholesteryl Ester Binding Protein) was resolved by the group at 2.2 A. It contains a long hydrphobic tunnel (~60 A) which sequesters its hydrophobic cargo and shields it from the aqueous environment of the blood. The entrances of the tunnel are blocked by the polar head group of a lipid- oleaylphosphatidyl choline. Remarkably, the group managed to crystallize the protein with four different molecules, all of which are important in lipid metabolism- cholesteryl oleate, triglycerides, and phoshatidyl choline. The overall shape of the protein is like a boomerang, and the authors surmise that the shape could help to latch on to an HDL particle.
It is sad that Torcetrapid failed. The binding of the drug had been intensively studied, and its potency had been evaluated with a high degree of confidence. In the end, the drug sank in the one foggy area where human prediction still fails- toxicity and side effects. The company has redeemed itself to some extent with this structure and hopefully, the structure will lead them to a safer version or analog of torcetrapib. Till then, it does no harm to study the structure for the sake of beauty alone.
Choosing the right perfume can be difficult and because it is also considered an intimate gift buying the wrong perfume can backfire on you and get you the opposite result of that which you hoped for.
ReplyDeleteThe first thing you need to do is do some homework, meaning research. Look at your lady's perfume bottles, the ones that are nearly empty will be her favorites. If there is one there that is nearly full chances are she doesn't wear it often or doesn't like it. Hint around and ask her what types of fragrances she likes and dislikes.
Humans are very sensory oriented and our sense of smell is no different. Certain perfumes can elicit strong reactions in both the wearer and the person reacting to the scent. Perfumes are made not only to attract but to also relax someone. If you aren't totally sure what kind of perfume to buy you can always play it safe and get something in the aromatherapy line. If you go this route, bear in mind that vanilla scents are considered to relax and a peppermint or lemon scent will be more stimulating.