Field of Science

New kid on the GPCR block

The CXCR4 GPCR structure has been solved by Raymond Stevens's group at Scripps. It joins the exclusive august list of previously crystallized GPCRs- the beta-adrenergic, rhodopsin and the adenosine A2A receptor.

This could be quite important for HIV drug discovery since the CXCR4 is a chemokine receptor expressed on the surface of lymphocytes that HIV uses as a co-receptor to gain entry into cells. People struggling with structure-based drug design with CXCR4 should be elated.

Welcome to the club, although many more members have to be still inducted.

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