Information on the course:
- The course: D001x Medicinal Chemistry
- Host platform: edX
- Date: Starts 10/5/15, but enrollment is open until 12/11/15
- Length: 8 weeks
- Cost: free
- Time: 6-8 h/wk for all content, 1 h/wk to peruse the video lectures
- Pre-req: chem (organic functional groups, line-angle structures), biology (parts of cell), math (logarithms & exponents)
- Topics (~1 wk per topic)
- Drug Approval (early drugs, regulatory process, cost, IP concerns)
- Enzymes & Receptors (inhibition, Ki, ligand types, Kd)
- Pharmacokinetics (Vd, clearance, compartment models)
- Metabolism (phase I & II reactions, CYP450 isoforms, prodrugs)
- Molecular Diversity (binding, drug space, combi chem, libraries)
- Lead Discovery (screening, filtering hits, drug metrics)
- Lead Optimization (functional group replacements, isosteres, peptidomimetics)
- Case Studies on Selected Drug Classes
- Bonus features
- Interviews with pharma professionals, including scientists from Novartis (a partner on the course)
- Virtual labs involving online tools for predicting drug-relevant activity
- Target audience: pre-med students, graduate students, recent pharma hires, research assistants
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