Shot
Nice replacement to preserve overall electronic characteristics such as HBonding, but increase absorbtion and lipophilicity, and decrease basicity. From a nice review on FactorXa inhibitor development from Structure-Based Drug Discovery
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Showing posts with label guanidine. Show all posts
Showing posts with label guanidine. Show all posts
Amidine-aminoisoquinoline substitution
Shot
Nice replacement to preserve overall electronic characteristics such as HBonding, but increase absorbtion and lipophilicity, and decrease basicity. From a nice review on FactorXa inhibitor development from Structure-Based Drug Discovery
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