But Murcko thought it prudent to not name the scientist!
Yesterday, randomly flipping through a review by a well-known scientist, I came across this statement
"The ability to design drugs (so-called ‘ rational drug design ’) has been one of the long-term objectives of chemistry for 50 years. It is an exceptionally difficult problem, and many of its parts lie outside the expertise of chemistry. The much more limited problem – how to design tight-binding ligands (rational ligand design) – would seem to be one that chemistry could solve, but has also proved remarkably recalcitrant. The question is ‘Why is it so difficult ? ’ and the answer is ‘We still don’t entirely know’."Needless to say, I get the very strong feeling that Murcko was talking about this particular scientist. I have to say that my own opinions swing toward those enumerated by the scientist. Care to guess who?? (One hint: conference and company location...)