3. Nature beats human beings...again. The first example of an enzyme that seems to be exclusively commited to catalyzing Diels-Alder reactions. Otto and Kurt would have been disappointed (or ecstatic, depending on how you see it).
4. The use of scaffold proteins to facilitate synthetic biology. This kind of work is hugely exciting. Whenever we discuss synthetic biology papers in our lab meetings, it's the only time when we feel like we have truly stepped into a time portal. The possibilities are endless, with the most practically exciting being the modular assembly of genes from different organisms to funnel reaction intermediates and produce virtually any natural or synthetic molecule we want on demand.