"The amount of energy released when a nucleus undergoes fission can be calculated by determining the net decrease in mass, from the known isotopic masses, and utilizing the Einstein mass-energy relationship. A simple, but instructive although less accurate, alternative procedure is the following. Disregarding the neutrons involved, since they have a negligible effect on the present calculation, the fission reaction may be represented (approximately) by
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Field of Science
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Change of address1 year ago in Variety of Life
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Change of address1 year ago in Catalogue of Organisms
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Earth Day: Pogo and our responsibility1 year ago in Doc Madhattan
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What I Read 20241 year ago in Angry by Choice
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I've moved to Substack. Come join me there.1 year ago in Genomics, Medicine, and Pseudoscience
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Histological Evidence of Trauma in Dicynodont Tusks7 years ago in Chinleana
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Posted: July 21, 2018 at 03:03PM8 years ago in Field Notes
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Why doesn't all the GTA get taken up?8 years ago in RRResearch
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Harnessing innate immunity to cure HIV10 years ago in Rule of 6ix
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post doc job opportunity on ribosome biochemistry!11 years ago in Protein Evolution and Other Musings
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Blogging Microbes- Communicating Microbiology to Netizens11 years ago in Memoirs of a Defective Brain
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Re-Blog: June Was 6th Warmest Globally12 years ago in The View from a Microbiologist
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The Lure of the Obscure? Guest Post by Frank Stahl14 years ago in Sex, Genes & Evolution
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Lab Rat Moving House14 years ago in Life of a Lab Rat
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Goodbye FoS, thanks for all the laughs15 years ago in Disease Prone
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Slideshow of NASA's Stardust-NExT Mission Comet Tempel 1 Flyby15 years ago in The Large Picture Blog
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in The Biology Files
Simple, atypical but neat estimation of energy released in fission
How Niels Bohr predicted Rydberg atoms
In Niels Bohr's original 1913 formulation of the quantum atom, the Bohr radius r was proportional to n^2, n being the principal quantum number. Highly excited states would correspond to very large values of n and Bohr predicted these "giant" atoms would exist. Since the volume scales as r^3 or n^6, for n=33 you should see a "hydrogenic" atom a billion times larger than a ground state hydrogen atom. However, no spectral lines corresponding to such atoms were observed. So was Bohr's theory wrong?
Book review: "The Apocalypse Factory: Plutonium and the Making of the Atomic Age", by Steve Olson
In the history of the Manhattan Project, Los Alamos has always been the star, and Hanford and Oak Ridge where plutonium and uranium respectively were created have been supporting actors. Steve Olson's goal is to resurrect Hanford as the most important site in retrospect. Its product, plutonium, is now the element of choice in the vast majority of the world's nuclear arsenals. And the product of that creation has created an environmental catastrophe beyond reason.
Rutherford on tools and theories (and machine learning)
Ernest Rutherford was the consummate master of experiment, disdaining theoreticians for playing around with their symbols while he and his fellow experimentalists discovered the secrets of the universe. He was said to have used theory and mathematics only twice - once when he discovered the law of radioactive decay and again when he used the theory of scattering to interpret his seminal discovery of the atomic nucleus. But that's where his tinkering with formulae stopped.
Time and time again Rutherford used relatively simple equipment and tools to pull off seemingly miraculous feats. He had already won the Nobel Prize for chemistry by the time he discovered the nucleus - a rare and curious case of a scientist making their most important discovery after they won a Nobel prize. The nucleus clearly deserved another Nobel, but so did his fulfillment of the dreams of the alchemists when he transmuted nitrogen to oxygen by artificial disintegration of the nitrogen atom in 1919. These achievements justified every bit Rutherford's stature as perhaps one of two men who were the greatest experimental physicists in modern history, the other being Michael Faraday. But they also justified the primacy of tools in engineering scientific revolutions.
However, Rutherford was shrewd and wise enough to recognize the importance of theory - he famously mentored Niels Bohr, presumably because "Bohr was different; he was a football player." And he was on good terms with both Einstein and Eddington, the doyens of relativity theory in Europe. So it's perhaps not surprising that he pointed out an observation about the discovery of radioactivity attesting to the important of theoretical ideas that's quite interesting.
As everyone knows, radioactivity in uranium was discovered by Henri Becquerel in 1896, then taken to great heights by the Curies. But as Rutherford points out in a revealing paragraph (Brown, Pais and Pippard, "Twentieth Century Physics", Vol. 1; 1995), it could potentially have been discovered a hundred years earlier. More accurately, it could have been experimentally discovered a hundred years earlier.
Rutherford's basic point is that unless there's an existing theoretical framework for interpreting an experiment - providing the connective tissue, in some sense - the experiment remains merely an observation. Depending only on experiments to automatically uncover correlations and new facts about the world is therefore tantamount to hanging on to a tenuous, risky and uncertain thread that might lead you in the right direction only occasionally, by pure chance. In some ways Rutherford here is echoing Karl Popper's refrain when Popper said that even unbiased observations are "theory laden"; in the absence of the right theory, there's nothing to ground them.
It strikes me that Rutherford's caveat applies well to machine learning. One goal of machine learning - at least as believed by its most enthusiastic proponents - is to find patterns in the data, whether the data is dips and rises in the stock market or signals from biochemical networks, by blindly letting the algorithms discover correlations. But simply letting the algorithm loose on data would be like letting gold leaf electroscopes and other experimental apparatus loose on uranium. Even if they find some correlations, these won't mean much in the absence of a good intellectual framework connecting them to basic facts. You could find a correlation between two biological responses, for instance, but in the absence of a holistic understanding of how the components responsible for these responses fit within the larger framework of the cell and the organism, the correlations would stay just that - correlations without a deeper understanding.
What's needed to get to that understanding is machine learning plus theory, whether it's a theory of the mind for neuroscience or a theory of physics for modeling the physical world. It's why efforts that try to supplement machine learning by embedding knowledge of the laws of physics or biology in the algorithms are likely to work, while efforts blindly using machine learning to try to discover truths about natural and artificial systems using correlations alone would be like Rutherford's fictitious uranium salts from 1806 giving off mysterious radiation that's detected without interpretation, posing a question waiting for an explanation.
Steven Weinberg (1933-2021)
I was quite saddened to hear about the passing of Steven Weinberg, perhaps the dominant living figure from the golden age of particle physics. I was especially saddened since he seemed to be doing fine, as indicated by a lecture he gave at the Texas Science Festival this March. I think many of us thought that he was going to be around for at least a few more years.
Weinberg was one of a select few individuals who transformed our understanding of elementary particles and cemented the creation of the Standard Model (he coined the name), in his case by unifying the electromagnetic and weak forces; for this he shared the 1979 Nobel Prize in physics with Abdus Salam and Sheldon Lee Glashow. His 1967 paper which heralded the unification, "A Model of Leptons", was only 3 pages long and remains one of the most highly cited articles in physics history.
But what made Weinberg special was that he was not only one of the most brilliant theoretical physicists of the 20th century but also a pedagogical master with few peers. His many technical textbooks, especially his 3-volume "Quantum Theory of Fields", have educated a generation of physicists; meanwhile, his essays in the New York Times Book Review and other avenues and collections of articles published as popular books have educated the lay public about the mysteries of physics. But in his popular books Weinberg also revealed himself to be a real Renaissance Man, writing not just about physics but about religion, politics, philosophy, history including the history of science, opera and literature. He was also known for his political advocacy of science. Among scientists of his generation, only Freeman Dyson had that kind of range.
There have been some great tributes to him, and I would point especially to the ones by Scott Aaronson and Robert McNees, both of whom interacted with Weinberg as colleagues. The tribute by Scott especially shows the kind of independent streak that Weinberg had, never content to go with the mainstream and always seeking orthogonal viewpoints and original thoughts. In that he very much reminded me of Dyson; the two were in fact friends and served together on the government advisory group JASON, and my conversation with Weinberg which I describe below ended with him asking me to give my regards to Freeman, who I was meeting in a few weeks.
I had the good fortune of interacting with Steve on two occasions, both rewarding. The first time I had the opportunity to be with him on a Canadian television panel on the challenges of Big Science. You can see the discussion here:
https://www.tvo.org/video/the-challenge-of-big-science
The next time was a few years later when I contacted him about a project and asked whether he had some thoughts to share about it. Steve didn't know me personally (although he did remember the Big Science panel) and was even then very busy with writing and other projects. In addition, the project wasn't something close to his immediate interests, so I was surprised when not only did he respond right away but asked me to call him at 10 AM on a Sunday and spoke generously for more than an hour. I still have the recording.
Steve was a great physicist, a gentleman and a Renaissance Man, a true original. We are unlikely to see the likes of him for a long time.
One of the reasons I feel particularly wistful with his passing is because he was among the last of the creators of modern particle physics. He worked in an enormously fruitful time in which theory went hand in hand with experiment. This is different from the last twenty years in which fundamental physics and especially string theory have been struggling to make experimental connections. In cosmology however, there have been very exciting developments, and Weinberg who devoted his last few decades to the topic was certainly very interested in these. Hopefully fundamental physics can become as involved with the productive interplay of theory and experiment as cosmology and condensed matter physics are, and hopefully we can again resurrect the golden era of science in which Steven Weinberg played such a commanding role.
Chandra and Johnny come close to discovering black holes
This is from Jagdish Mehra and Helmut Rechenberg's monumental "The Historical Development of Quantum Mechanics, Vol. 6, Part 2". With Chandrasekhar's facility with astrophysics and von Neumann's with mathematics, there is little doubt in my mind that they would have succeeded.
As it happened, it was Oppenheimer and his student Hartland Snyder who wrote the decisive paper describing black holes in 1939.
The timing was bad, though; on the same day that the paper came out in the Physical Review, Germany attacked Poland and started World War 2. Far more consequential was another paper published on the same day in the same issue - John Wheeler and Niels Bohr's liquid drop model of nuclear fission.
Book review: Quantum mechanics and quantum mechanics. David Kaiser's "Quantum Legacies: Dispatches from an Uncertain World"
Big discoveries from little things
That's physicist Albert Michelson, at the University of Chicago in 1894, saying that fundamental physics was essentially finished. In the fifty years after Michelson's talk, physics discovered the following: special and general relativity, quantum theory, nuclear fission and the expansion of the universe. And it was just getting warmed up. The famously acerbic Wolfgang Pauli would have probably called Michelson's prediction as "not even wrong".
Michelson clearly was woefully wrong in saying that the main task of physics would henceforth simply be more accurate measurements. And yet it would be wrong to take him to task for a clearly mistaken view, for at least two reasons. Firstly, physics in 1894 explained an enormous range of phenomena. From Newtonian mechanics that explained everything from apples falling down to the motion of planets to thermodynamics which explained everything from the increase in disorder in physical systems to the practical workings of steam engines, physics clearly had proved itself to be a spectacularly successful science, so there was good reason to think that most of the fundamentals had been worked out.
Secondly, the kinds of things physics was being unable to explain then could be seen as little more than annoying anomalies and exceptions; the behavior of glowing blackbodies, the slight anomaly in the motion of mercury around the Sun, the absence of the luminiferous ether. In fact, Michelson himself would perform an experiment just three years later, in 1887, that would lead to a very important negative result: the lack of detection of the ether that had been predicted as a medium for the propagation of light and other electromagnetic radiation which Maxwell had worked out.
Neither Michelson nor anyone else could have seen the profound new worlds hidden in these seemingly mundane anomalies. Problems with blackbody radiation led to the birth of Planck's quantum theory, and problems with the ether and with the anomalous orbit of Mercury led to Einstein's special and general theories of relativity. And at least in one sense Michelson's highlighting of more and more accurate measurements was spot on: the difference between the perihelion of Mercury predicted by Newton's theory of gravity and what was actually measured was tiny - Newton's prediction was off only by a millionth of one percent (which meant that Mercury would arrive at its perihelion only half a second later than what Newton predicted), but that little deviation hid a stunningly different and new view of nature that took Einstein's genius to uncover.
Rather than mocking Michelson's 1894 statement as a foolish failure of prediction or the product of tunnel vision, it's more important therefore to recognize what it implies. Firstly, it's clear that nobody and not just Michelson could have known how different the future of physics would be, giving currency to Niels Bohr's statement that prediction is difficult, especially about the future. But more importantly, it's enlightening to realize how seemingly mundane experimental anomalies can lead to completely new ways of looking at the world.
In my view, the fifty years that followed Michelson's statement, although now rightly regarded as a triumph of theoretical physics, should be viewed as an even greater triumph of experimental physics. Both the old quantum theory invented by Planck and the new quantum theory invented by Heisenberg and others arose from small, anomalous observations in seemingly obscure and minor areas of physics. So did relativity. Without the exceedingly accurate measurement of the error in the predicted vs measured anomaly of Mercury's orbit, who knows how long it would have taken general relativity to come along.
The development of physics following Michelson's statement gives one hope that the biggest discoveries in science will continue to be hidden in some of the smallest discrepancies in experiment. This is especially true of biology where we are now in a position to detect very small differences in protein and gene expression. Experimentalists should keep on looking for minor anomalies in their observations; flies in the ointment; nagging little differences in numbers that should be explained by the existing theoretical framework but are not. Sometimes it will be nothing, often it will simply be a result of statistical error or random noise, but occasionally, just occasionally, it could be a glimpse of the crack of light from a door that opens on to a whole new world.
The birth of a new theory: Richard Feynman and his adversaries
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| Leading physicists discuss their field's most pressing problems at Shelter Island in April 1947; including, among others, Julian Schwinger, Richard Feynman and J. Robert Oppenheimer |






