Field of Science

Trans-biotin?

Questiion for all the synthetics out there: Does anyone know how common, if at all, is trans-biotin, where the two five-membered rings are fused in a trans manner? If not, how easy/hard is it to make it?

3 comments:

  1. This would be quite difficult. Most fused 5,5-ring systems (as found in biotin) are cis only. This is nice in making such molecules as it is almost impossible to make the wrong (trans) isomer

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  2. There are a few examples that occur in natural products. For example, there were three papers that appeared just this year reporting a revised structure for palau'amine.

    Tex

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  3. Anon: Yep, that's why I was wondering. But maybe I thought there were ways to make them.

    Tex, thanks

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