The worst thing that could happen to you after working on a conformational analysis for three months: suddenly thinking that you might have gotten the stereochemistry of one or more of the 11 stereocenters in your molecule wrong.
The best thing that could happen to you after working on a conformational analysis for three months: checking the 11 stereocenters and finding that all of them are correct.
Painful, really.
Field of Science
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Why drug discovery is hard, part 2: On the unpredictable and complicated origins of drug species
2 days ago in The Curious Wavefunction -
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